additional information on betulinic acid including comments from John Pezzutto of the University of Illinois at Chicago, whose lab led the melanoma research, can be found in the electronic news magazine Environews at:
scroll down to the article titled: Barking Up the Right Tree. Then check:
journal article on betulinic acid and melanoma:
Pisha E., H. Chai, I.S. Lee, et al. 1995. Discovery of betulinic acid as a selective inhibitor of human melanoma. Nature Medicine 1(10): 1046-51.
journal articles on betulinic acid and HIV:
Kashiwada, Y., F. Hashimoto, L.M. Cosentino, et al. 1996. Betulinic acid and dihydrobetulinic acid derivatives as potent HIV agents. Journal of Medicinal Chemistry 39(5): 1016-1017.;
Evers M., c. Poujade, F. Soler, et al. Betulinic acid derivatives: a new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action. 1996. Journal of Medicinal Chemistry 39(5): 1056-1068.;
Soler, F., C. Poujade, M.Evers, et al. 1996. Betulinic acid derivatives: a new class of specific inhibitors of human immunodeficiency virus type 1 entry, Journal of Medicinal Chemistry 39(5): 1069-83.
EBL HOME PAGE