Ethnobotanical Leaflets 12: 373-387. 2008.
Origins of Plant Derived Medicines
M. Maridass* and A. John De Britto
Animal Health Research Unit & Plant Molecular biology Research Unit
St.Xavier’s College (Autonomous)
This review article describes the origins of plant derived medicines that have been developed as a result of traditional knowledge being handed down from one generation to the next. Various industries are now searching into sources of alternative, more natural and environmentally friendly antimicrobials, antibiotics, diabetics, antioxidants and crop protection agents. Medicinal plants have provided a good source of a wide variety of compounds, such as phenolic compounds, nitrogen compounds, vitamins, terpenoids and some other secondary metabolites, which are rich in valuable bioactivities, e.g., antioxidant, anti-inflammatory, antitumor, antimutagenic, anti-carcinogenic, antibacterial, or antiviral activities. Medicinal plants have become the main object of chemists, biochemist, and pharmaceutics. Their research plays an important role for discovering and developing new drugs that hopefully have more effectiveness and no side actions like most modern drugs.
Origin of Medicine
Fossil records revealed that the human use of plants as traditional medicine date back to middle Paleolithic age, approximately 60,000 years ago (Solecki et al., 1975). The plants were used as flavors, foods, insect deterrents, ornamentals, fumigants, spices, and cosmetics (Kunin et al., 1996; Pieroni et al., 2004). Generally, the medicinally useful plants are sold as commodities in the market, and those that are sold for medicinal purposes dominate the market (Runner et al., 2001). At present, natural products (and their derivatives and analogs) represent over 50% of all drugs in clinical use, in which natural products derived from higher plants represent ca. 25% of the total (Alandrin et al., 1998). The World Health Organization estimated that over 80% of the people in developing countries rely on traditional remedies such as herbs for their daily needs (Tripathi et al., 2003), and about 855 traditional medicines include used crude plant extracts. This means that about 3.5 to 4 billion of the global population rely on plants resources for drugs (Farnsworth, 1988).
Many infectious diseases are known to be treated with herbal remedies throughout the history of mankind. The maximum therapeutic and minimum side effects of herbal remedies have demonstrated or verified in numerous scientific investigations. Even today, plant materials continue to play a major role in primary health care as therapeutic remedies in many developing countries (Czygan, 1993; Ody, 1993).
Market Demands of Medicinal Plants
Nearly 95 percentage of
plants used in traditional medicines are collected from forests and other
natural sources. The plants collected from different sources show wide disparity
in therapeutic values and also much variation in market rates. In the recent
years there has been greater expansion of indigenous drug industry in
New medicines have been discovered with traditional,
empirical and molecular approaches (
Table 1. Currently used Drugs in the United States that are obtained from flowering Plants.
Natural products have provided many effective drugs. These include a wide range of older drugs such as quinine (Kremsner et al., 1994) and morphine (Benyhe et al., 1994) and newer drugs such as paclitaxel (TaxolTM) (Wani et al., 1971), camptothecin (Wall et al., 1966), etoposide (Endo et al., 1976), mevastatin (Keller-Juslén, et al., 1971), and artemisinin (Klayman, 1985). Further evidence of the importance of natural products is provided by the fact that almost half of the world’s 25 best selling pharmaceuticals in 1991 were either natural product or their derivatives (O’Neill, 1993).
The number of higher plant species (angiosperms and gymnosperms) on planet earth is estimated around 250,000 (Ayensu et al., 1978), with a lower level at 215,000 (Cronquist, 1981) and an upper level high as 500,000 (Tippo et al., 1977; Schultes, 1972). Of these, only about 6% have been screened for biological activity, and only 15% have been pharmacologically screened. Moreover, plant extracts contain up to several thousands of secondary metabolites. The major types of compounds identified in Indian medicinal herbs include alkaloids, saponin, flavonoids, anthroquinones, terpenoids, coumarins, lignans, polysaccharides, polypeptides and proteins. Efficient detection and rapid characterization of these components on a molecular basis offer better understanding of the pharmacological application of Indian herbal medicines.
Plant-Derived Drugs from Traditional Systems of Medicine
For thousands of years, plant-derived (herbal) remedies
have remained a vital part of traditional Chinese medicine, and even today it
constitute about a 30% to 50% proportion of the total drug therapy for a
fifth of the world’s population who live in the People’s Republic of
The drugs commonly used in People’s Republic of China PRC include tropane alkaloids anisodamine and anisodine from Scopolia tangutica, which are employed as a mild, naturally acting anticholinergic agent for septic shock in cases of bacillary dysentery, and in the treatment of migrane headache. An isoquinoline alkaloid, racemic tetrahydropalmatine, from Corydalis ambigua is used as an analgesic and tranquilizer, and indirubrin, a nitrogen-containing metabolite produced by Indigofera tinctoria, is effective in the treatment of chronic myelocytic leukemia (Xiao and Fu, 1987; Han et al., 1988).
Plant-Derived Antibacterial Chemotherapeutants
Infectious disease is the number one cause of death accounting for approximately one-half of all deaths in tropical countries. Death from infectious diseases, ranked 5th in 1981, has become the 3rd leading cause of death in 1992, with an increase of 58% (Pinner et al., 1996).
More than hundreds of plants world wide are used in traditional medicine as treatments for bacterial infection (Martin et al., 2003). Although many have been treated by conventional pharmaceutical approaches, there is a growing interest in the use of natural products by the general public. In addition the pharmaceutical industry continues to examine their potential as sources novel growth factor, immunomodulatory and antimicrobial activity (Ghose et al., 2003).
Plant-Derived Wound Healing Agents
Wound healing occupies an important field of research in modern biomedical sciences. Wound healing involves cellular, physiological, biochemical and molecular processes which result ultimately in connective tissue repair and the formation of a fibrous scar (Peacock, 1988). Wound healing process uses a combination of three mechanisms. Contraction is the major method by which wound healing occurs at an amputation site, such as the tip of a finger. Epithelisation predominates in the healing of abrasions and connective tissue deposition occurs when lacerations are sutured and closed (Cockbill et al., 2000).
Healing of wound is an important part of the reparative process. A detailed pathophysiology of wound was better understood following the establishment of the theory of a cell signal cascade system involved in the formation of new tissues repairing the wound. Like the alchemist’s dream of turning base metal into gold, efforts aimed at achieving a perfect wound healing has inspired many researchers in trying various therapeutic options which were thought to aid or accelerate the wound healing process. The cheaper and more effective the agent, may be better for the patient. Durodola (1977) demonstrated the effectiveness of crude extract of Ageratum conyzoides in inhibiting the growth of Staphylococcus aureus, a major wound pathogen in in-vitro cultures of the organism. Much work has recently been done on the wound healing effect of several medicinal plants (Oladejo et al., 2003; Biswas et al., 2003; Abo et al., 2004; Biswas et al., 2004).
Plant-Derived Anti-Diarrhoeal Agents
Diarrhoea is a major health problem especially for children under the age of 5 years and up to 17% of all death in the indoor pediatric patients is related to diarrhoea. Worldwide incidence of diarrhoeal death account for more than 5-8 million each year in infants and small children less than 5 year especially in developing countries (Fauci et al., 1998). According to WHO estimate for the year 1998, there were about 7.1 million deaths due to diarrhoea (Park et al., 2000). A range of medicinal plants with anti-diarrhoeal properties has been widely used by the traditional healers; however, the effectiveness of many of these anti-diarrhoeal traditional medicines have not been scientifically evaluated (Chitme et al., 2004).
Plant-Derived Anti-Diabetic Agents
There are 143 million people worldwide
suffering from diabetes, almost five times more than the estimates ten years
ago. This number may probably double by the year 2030. Therefore, the global
human population appears to be in the midst of an epidemic of diabetes.
Reports from the World Health Organization (WHO) indicate that diabetes
mellitus is one of the major killers of our time, with people in
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. It may be secondary to a deficiency or disturbance in the secretion of insulin or to an abnormal response of peripheral tissues to insulin. The resulting metabolic derangement of the intermediary metabolism of carbohydrate, lipid, and protein affects all organ systems but most prominent in the arteries, arterioles, and capillaries (Damjanov et al., 1996). There are two main categories of this disease. Type 1 diabetes mellitus also called insulin-dependent diabetes mellitus (IDDM) and Type 2, the non-insulin-dependent diabetes mellitus (NIDDM). IDDM represents a heterogenous and polygenic disorder, with a number of non-HLA loci (about 20) contributing to the disease susceptibility. Though this form of diabetes accounts for 5 to 10% of all cases, the incidence is rapidly increasing in specific regions. It is estimated that incidence of Type 1 diabetes will be about 40% higher in the year 2010 than in 1997, and yet there is no identified agent substantially capable of preventing this type of disease. NIDDM is far more common and results from a combination of defects in insulin secretion and action. This type of disease accounts for 90 to 95% of all diabetic patients. Treatment of type 2 diabetes is complicated by several factors inherent to the disease process, typically, insulin resistance, hyperinsulinemia, impaired insulin secretion, and reduced insulin-mediated glucose uptake and utilization (Tiwari and Madhusudana Rao, 2002).
The recommended use of plants in the treatment for diabetes needs to be evaluated. Plants are important not only for the control of type 2DM but also for its prevention, especially for people with elevated levels of blood glucose and blood intolerance who have a greater risk of developing diabetes (Anderson et al., 2004). Botanical products can improve glucose metabolism and the overall condition of individuals with diabetes not only by hypoglycemic effects but also by improving lipid metabolism, antioxidant status, and capillary function (Bailey et al., 1989). A number of medicinal/culinary herbs have been reported to yield hypoglycemic effects in subjects with diabetes. These include cinnamon, cloves, bay leaves, turmeric (Khan et al., 1990), bitter melon (Srivastava et al., 1993; Raman and Lau, 1996), gurmar (Basakaran et al., 1990; Shanmugasundaram et al., 1990; Bishayee and Chatterjee, 1994), Korean ginseng (Sotaniemi et al., 1995), onions and garlic (Koch and Lawson, 1996), holy basil (Rai et al., 1997).
Table 2. Chemical drugs and drugs from medicinal plants.
Plant-Derived Drugs from Chinese Herbal Remedies and Other Systems of Traditional Medicine
During the past decade, traditional systems of medicine have become a topic of global importance. Current estimates suggest that, in many developing countries, a large proportion of populations relies heavily on traditional practices and medicinal plants may be available in these countries, herbal medicines (phytomedicines) have often maintained popularity for historical and cultural reasons. Concurrently, many people in developed countries have begun to turn to alternative or complementary therapies, including medicinal herbs.
Chinese Traditional Medicine
Traditions of plant-collecting and plant based
medications have been handed down from generation to
generation. For thousands of years, plant-derived (herbal) remedies
have remained a vital part of traditional Chinese medicine, and even today
constitute about a 30% to 50% proportion of the total drug therapy for a
fifth of the world’s population who live in the People’s Republic of
Examples of plant drugs that are of use in the PRC include the tropane alkaloids anisodamine and anisodine from Scopolia tangutica, which are employed as a mild, naturally acting antichol inergic agent for septic shock in cases of bacillary dysentery, and as a migraine treatment, respectively. An isoquinoline alkaloid, racemic tetrahydropalmatine, from Corydalis ambigua is used as an analgesic and tranquilizer, and indirubrin , a nitrogen-containing metabolite produced by Indigofera tinctoria, is effective in the treatment of chronic myelocytic leukemia.
Conclusion of our research article reported that traditional knowledge on medicinal plants plays a vital role in the primary health care and has potential of the discovery of new herbal drugs, new sources of pharmaceuticals, contraceptives and for sustainable utilization of medicinal plants genetic resources and their conservation.
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