Ethnobotanical Leaflets 13: 213-14. 2009.

 

 

Pharmacological Activities of Mentha piperita- Mini Review

 

S. Meenatchisundaram1*, G. Parameswari1, Diana Sunny1, M. Brinda2, T. Subbraj1,  T. Suganya1 and A. Michael1

 

1Department of Microbiology, PSG College of Arts and Science, Coimbatore, India

2Department of Microbiology, GRD College of Science, Coimbatore, India

*Corresponding author: Dr.S.Meenatchisundaram, E-Mail: drmscbe@gmail.com

 

Issued 30 January 2009

 

Peppermint (Mentha × piperita) is a hybrid mint, a cross between watermint (Mentha aquatica) and spearmint (Mentha spicata). The plant is indigenous in Europe and now widespread in cultivation throughout all regions of the world. It is found wild occasionally with its parent species

 

Pharmacological Activities of Mentha piperita

Antimicrobial activity

Extracts of Folium Menthae Piperitae have antibacterial and antiviral activity in vitro. Addition of ground leaves to the agar medium inhibited the growth of Salmonella typhimurium, Staphylococcus aureus and Vibrio parahaemolyticus at concentrations of 0.1–2.0% (w/v). Aqueous and ethanol extracts of the leaves reduced the number of plaques of the rinderpest virus at concentrations of 4–8mg/ml1. Aqueous extracts of the leaves demonstrated activity against the following viruses in egg and cell culture: Newcastle disease, herpes simplex, vaccinia, Semliki Forest and West Nile2.

 

Smooth muscle contraction

A 31% ethanol extract of the leaves inhibited both acetylcholine- and histamine-induced smooth muscle contractions in guinea-pig ileum in vitro at a concentration of 10 ml/l. The results were similar to those obtained with 0.13 mg atropine3,4. An aqueous flavonoid fraction isolated from a leaf extract inhibited barium chloride-induced muscle contractions of guinea-pig ileum in vitro at a concentration corresponding to                     0.5 g leaves/ml5.

 

Choleretic activity

Injection of a leaf infusion (0.5 ml) or a flavonoid fraction (equivalent to 3.3 g leaves/kg body weight) increased the amount of bile acids in cannulated rats and dogs (dose 0.4 mg/kg body weight)5,6. A mixture of flavonoids, isolated from the leaves, had choleretic activity in dogs (2mg/kg body weight)7. Flavomentin, a flavonoid isolated from the leaves, stimulated bile secretion and the synthesis of bile acids in dogs (2mg/kg body weight)8. Intragastric administration of a 30% ethanol extract of the leaves to rats (1ml/kg body weight) increased bile flow by 43%. The extract did not induce sedation in mice at doses up to 10 ml/kg body weight4.

 

Anti-oedema activity

Topical application of a methanol leaf extract to mice (2.0mg/ear) inhibited ear oedema induced by 12-O-tetradecanoylphorbol-13-acetate9.

 

Analgesic activity

Intragastric administration of a 30% ethanol extract of the leaves inhibited phenylbenzoquinone-induced writhing in mice (ED50 2.1 ml/kg body weight)4.

 

Toxicology

Intragastric administration of a leaf extract (50 g leaves infused with 500 ml hot water for 10 minutes, then spray-dried) to 12 mice (4 g/kg body weight as a single dose) did not result in central nervous system depression, toxic effects or mortality10.

 

References

1. Alwan AH. Antiviral activity of some Iraqi indigenous plants. International

    Journal of Crude Drug Research, 1988, 2:107–111.

2. Herrmann EC Jr, Kucera LS. Antiviral substances in plants of the mint family

   (Labiatae). III. Peppermint (Mentha piperita) and other mint plants. Proceedings of the

   Society for Experimental Biology and Medicine, 1967:874–878.

 

3. Forster HB. Antispasmodic effects of some medicinal plants. Planta Medica,

    1980, 40:309–319.

4. Leslie GB. A pharmacometric evaluation of nine Bio-Strath herbal remedies. Medita,

    1978, 8:3–19.

5. Lallement-Guilbert N, Bézanger-Beauquesne L. Recherches sur les flavonoides

    quelques Labiees médicinales (romarin, menthe poivrée, suage officinale). Plantes

    médicinales et Phytothérapie, 1970, 4:92–107.

6. Steinmetzer K. Experimentelle Untersuchungen über Cholagoga. Wiener Klinische

    Wochenschrift, 1926, 39:1418–1422, 1455–1457.

7. Pasechnik IK. Study of choleretic properties specific to flavonoids from Mentha

    piperita leaves. Farmakologiia Toksikologiia, 1966, 21:735–737.

8. Pasechnik IK, Gella EV. Choleretic preparation from peppermint. Farmatsevtychnyi

    Zhurnal (Kiev), 1966, 21:49–53.

9. Yasukawa K. Inhibitory effect of edible plant extracts on 12- Otetradecanoylphorbol- 13-

     acetate-induced ear edema in mice. Phytotherapy  Research, 1993, 7:185–189.

10. Della Loggia R. Evaluation of some pharmacological activities of a peppermint

      extract. Fitoterapia, 1990, 61:215–221.